Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | PGR | P06401 | 6/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6066170 | 0.79 | ABCB1 (0.31) | ABCB1 | |
| SCHEMBL6066138 | 0.77 | HRH3 (0.44) | HRH3HSD11B1 | |
| SCHEMBL5016018 | 0.75 | HTR7 (0.38) | HRH3PGRHTR7GRM4CYP19A1 | |
| SCHEMBL26182854 | 0.71 | AR (0.35) | HTR7 | |
| SCHEMBL5024896 | 0.70 | CYP11B1 (0.39) | HRH3HTR7CYP11B1CYP11B2 | |
| SCHEMBL30462894 | 0.70 | HRH3 (0.52) | HRH3 | |
| SCHEMBL11553307 | 0.67 | KMT2A (0.48) | HTR7GRM4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL6066315 | 0.64 | ALDH1A1 (0.33) | ABCB1 | |
| SCHEMBL5024509 | 0.63 | USP14 (0.44) | CYP19A1CYP11B1CYP11B2SLC6A4 | |
| SCHEMBL17514714 | 0.62 | DRD2 (0.37) | PGRHTR7ABCB1CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660455-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005016890-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2005-02-24 | — | — | WO | disclosed |