SCHEMBL6066254

SCHEMBL6066254

CC1=Cc2ccccc2C1[Si](C)(C)NC(C)(C)C

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3811480 0.98 ALDH1A1 (0.30) ALDH1A1LMNA
SCHEMBL7630825 0.80 LMNA (0.31) LMNA
SCHEMBL5088233 0.79
SCHEMBL16393781 0.79 USP2 (0.32)
SCHEMBL7055976 0.79 CYP11B1 (0.33) ALDH1A1LMNA
Hydrochloric Acid SCHEMBL6860527 0.78
Hydrochloric Acid SCHEMBL6858492 0.78 ALDH1A1 (0.30) ALDH1A1LMNA
SCHEMBL7567494 0.78 LMNA (0.34) LMNA
Hydrochloric Acid SCHEMBL6862648 0.78 ALDH1A1 (0.30) ALDH1A1LMNA
Hydrochloric Acid SCHEMBL6860531 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0889911-B1 METALLOCENE COCATALYST DOW CHEMICAL CO (US) 2000-11-02 EP claimed
EP-0891381-B2 OLEFIN SOLUTION POLYMERIZATION DOW CHEMICAL CO (US) 2006-05-24 EP disclosed
EP-0980375-B1 N-SILYLATED COMPOUND SYNTHESIS BOULDER SCIENT CO (US) 2005-11-09 EP disclosed
EP-0980375-A4 SILYLATED AND N-SILYLATED COMPOUND SYNTHESIS BOULDER SCIENT CO (US) 2003-01-22 EP disclosed
EP-0874860-B1 SUBSTITUTED INDENYL CONTAINING METAL COMPLEXES AND OLEFIN POLYMERIZATION PROCESS DOW CHEMICAL CO (US) 2002-11-13 EP disclosed
US-6410767-B2 USING N-SILYLATED MONO(CYCLOPENTADIENYL) LIGAND BOULDER SCIENTIFIC CO. 2002-06-25 US disclosed
US-20010056199-A1 Silylated and N-silylated compound synthesis BOULDER SCIENTIFIC COMPANY 2001-12-27 US disclosed
EP-0891381-B1 OLEFIN SOLUTION POLYMERIZATION DOW CHEMICAL CO (US) 2001-12-12 EP disclosed
US-6180810-B1 SILYL AMINES WHICH BOND COVALENTLY TO METAL CENTER OF COMPLEX TO PROVIDE OLEFIN POLYMERIZATION CATALYST COMPONENT BOULDER SCIENTIFIC COMPANY 2001-01-30 US disclosed
US-6087518-A Silylated and N-silylated compound synthesis BOULDER SCIENTIFIC COMPANY (US) 2000-07-11 US disclosed
EP-0980375-A1 N-SILYLATED COMPOUND SYNTHESIS BOULDER SCIENTIFIC COMPANY (US) 2000-02-23 EP disclosed
US-6015868-A CATALYSIS OF HIGH TEMPERATURE, SOLUTION POLYMERIZATION WHICH YIELDS HIGH MOLECULAR WEIGHT OLEFIN POLYMERS, BY USING COORDINATION CATALYST MIXED WITH AN ACTIVATING COCATALYST, EFFICIENCY THE DOW CHEMICAL COMPANY (US) 2000-01-18 US disclosed
WO-1999038871-A1 SILYLATED AND N-SILYLATED COMPOUND SYNTHESIS BOULDER SCIENTIFIC COMPANY (US) 1999-08-05 WO disclosed
EP-0563365-A1 PREPARATION OF METAL COORDINATION COMPLEX THE DOW CHEMICAL COMPANY (US) 1993-10-06 EP disclosed
WO-1993008199-A1 PREPARATION OF METAL COORDINATION COMPLEX THE DOW CHEMICAL COMPANY (US) 1993-04-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010056199-A1 Silylated and N-silylated compound synthesis LSS, NCL, FNTA ALDH1A1 2906/4885LMNA 1087/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.