Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288623 | 0.83 | S1PR1 (0.36) | PREPFAPS1PR1CYP2C9 | |
| SCHEMBL288373 | 0.80 | GPR119 (0.58) | GPR119CYP2C9 | |
| SCHEMBL290305 | 0.80 | GPR119 (0.45) | GPR119CYP2C9 | |
| SCHEMBL5201630 | 0.77 | GPR119 (0.53) | GPR119CYP2C9 | |
| SCHEMBL6066337 | 0.74 | GPR119 (0.58) | GPR119CYP2C9 | |
| SCHEMBL17559337 | 0.69 | GPR119 (0.49) | GPR119S1PR1 | |
| SCHEMBL16503907 | 0.68 | GPR119 (0.58) | GPR119CYP2C9 | |
| SCHEMBL29986931 | 0.68 | ALDH1A1 (0.38) | GPR119 | |
| SCHEMBL557714 | 0.67 | S1PR1 (0.50) | S1PR1 | |
| SCHEMBL1066568 | 0.66 | GPR119 (0.57) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504342-A1 | IMIDAZO-PYRAZOLES AS GPR119 INHIBITORS | Pfizer Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| EP-2480551-A1 | GPR 119 MODULATORS | Pfizer Inc. (US) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011061679-A1 | IMIDAZO-PYRAZOLES AS GPR119 INHIBITORS | PFIZER INC. (US) | 2011-05-26 | — | — | WO | disclosed |
| WO-2011036576-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2011-03-31 | — | — | WO | disclosed |