Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.42 |
| ▸ | S100A10 | P60903 | 1/20 | 0.42 |
| ▸ | SERPINH1 | P50454 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL576260 | 0.86 | MEN1 (0.48) | MAPK1CYP3A4TSHRMAPTMEN1 | |
| SCHEMBL9647870 | 0.86 | CYP3A4 (1.00) | MAPK1CYP3A4TSHRMAPTMEN1 | |
| SCHEMBL9485438 | 0.86 | CYP3A4 (1.00) | MAPK1CYP3A4TSHRMAPTMEN1 | |
| SCHEMBL1098379 | 0.86 | CYP3A4 (1.00) | MAPK1CYP3A4TSHRMAPTMEN1 | |
| SCHEMBL10813732 | 0.86 | CYP3A4 (1.00) | MAPK1CYP3A4TSHRMAPTMEN1 | |
| SCHEMBL9485453 | 0.86 | CYP3A4 (1.00) | MAPK1CYP3A4TSHRMAPTMEN1 | |
| 4,4'-Thiodianiline SCHEMBL49068 | 0.86 | CYP3A4 (1.00) | MAPK1CYP3A4TSHRMAPTMEN1 | |
| SCHEMBL9649030 | 0.86 | CYP3A4 (1.00) | MAPK1CYP3A4TSHRMAPTMEN1 | |
| SCHEMBL9649049 | 0.86 | CYP3A4 (1.00) | MAPK1CYP3A4TSHRMAPTMEN1 | |
| SCHEMBL9647766 | 0.86 | CYP3A4 (1.00) | MAPK1CYP3A4TSHRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118852135-A | N-acyl sulfonamide compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-10-29 | — | — | CN | disclosed |
| EP-2739626-B1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INT BV (NL) | 2016-05-04 | — | — | EP | disclosed |
| EP-2739626-B1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INT BV (NL) | 2016-05-04 | — | — | EP | disclosed |
| US-9096599-B2 | Spiroindoline compounds | INTERVET INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-9096599-B2 | Spiroindoline compounds | INTERVET INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-9096599-B2 | Spiroindoline compounds | INTERVET INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140163056-A1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INC. | 2014-06-12 | — | — | US | disclosed |
| US-20140163056-A1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INC. | 2014-06-12 | — | — | US | disclosed |
| US-20140163056-A1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INC. | 2014-06-12 | — | — | US | disclosed |
| EP-2739626-A1 | NOVEL SPIROINDOLINE COMPOUNDS | Intervet International B.V. (NL) | 2014-06-11 | — | — | EP | disclosed |
| WO-2013017678-A1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INTERNATIONAL B.V. (NL) | 2013-02-07 | — | — | WO | disclosed |
| WO-2013017678-A1 | NOVEL SPIROINDOLINE COMPOUNDS | INTERVET INTERNATIONAL B.V. (NL) | 2013-02-07 | — | — | WO | disclosed |
| US-7091227-B2 | Benzothiazole derivatives | ABBOTT GMBH & CO. KG (DE) | 2006-08-15 | — | — | US | disclosed |
| US-20030153568-A1 | Benzothiazole derivatives | BASF AKTIENGESELLSCHAFT LUDWIGSHAFEN, GERMANY | 2003-08-14 | — | — | US | disclosed |
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |
| EP-0102476-B1 | METHOD OF MODULATING THE IMMUNE RESPONSE SYSTEM IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1986-11-05 | — | — | EP | disclosed |
| US-4532349-A | 2-Amino-4'(phenylsulfonyl) acetanilides | AMERICAN CYANAMID COMPANY (US) | 1985-07-30 | — | — | US | disclosed |
| EP-0102476-A1 | Method of modulating the immune response system in mammals | AMERICAN CYANAMID COMPANY (US) | 1984-03-14 | — | — | EP | disclosed |
| US-4072696-A | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity | SYNTEX (U.S.A.) INC. (US) | 1978-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153568-A1 | Benzothiazole derivatives | TK1, FLT1, CDK1 | MAPK1 149/4885CYP3A4 1122/4885TSHR 2355/4885 |
| US-20140163056-A1 | NOVEL SPIROINDOLINE COMPOUNDS | PKD2, PKD1, REN | MAPK1 2303/4885CYP3A4 295/4885TSHR 3558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.