Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068479 | 0.87 | DRD2 (0.54) | RECQLDRD2DRD3ADRA1AHTR1A | |
| SCHEMBL7758380 | 0.86 | DRD2 (0.61) | DRD2DRD3ADRA1AHTR1AMEN1 | |
| SCHEMBL6068170 | 0.84 | DRD2 (0.52) | RECQLDRD2DRD3ADRA1AIGF1R | |
| SCHEMBL6068222 | 0.82 | DRD2 (0.53) | DRD2MEN1KMT2A | |
| SCHEMBL6068410 | 0.82 | DRD2 (0.50) | RECQLDRD2DRD3ADRA1AIGF1R | |
| Hydrochloric Acid SCHEMBL6313945 | 0.82 | RECQL (0.52) | RECQLDRD2DRD3ADRA1AIGF1R | |
| SCHEMBL6068501 | 0.80 | ADRA1A (0.55) | RECQLDRD2DRD3ADRA1AHTR1A | |
| SCHEMBL13698446 | 0.80 | DRD2 (0.61) | DRD2DRD3ADRA1AHTR1A | |
| SCHEMBL6068266 | 0.77 | GAA (0.49) | DRD2DRD3HTR1AMEN1KMT2A | |
| SCHEMBL6068305 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518272-B2 | HT3 receptor agonists and antagonists; treatment of anxiety, depression, cognitive deficits, and prostate cancer | WYETH | 2003-02-11 | — | — | US | claimed |
| US-20020156075-A1 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | WYETH (FORMERLY AMERICAN HOME PRODUCTS CORPORATION) (US) | 2002-10-24 | — | — | US | claimed |
| US-6376494-B1 | USED IN THE TREATMENT OF ANXIETY AND DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION | 2002-04-23 | — | — | US | claimed |
| US-7049330-B2 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | WYETH (US) | 2006-05-23 | — | — | US | disclosed |
| US-20030139449-A1 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | WYETH (US) | 2003-07-24 | — | — | US | disclosed |
| US-6518272-B2 | HT3 receptor agonists and antagonists; treatment of anxiety, depression, cognitive deficits, and prostate cancer | WYETH | 2003-02-11 | — | — | US | disclosed |
| US-20020156075-A1 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | WYETH (FORMERLY AMERICAN HOME PRODUCTS CORPORATION) (US) | 2002-10-24 | — | — | US | disclosed |
| US-6376494-B1 | USED IN THE TREATMENT OF ANXIETY AND DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION | 2002-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139449-A1 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | HTR5A, MC5R, CHRNA5 | RECQL 3148/4885DRD2 59/4885DRD3 65/4885 |
| US-20020156075-A1 | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents | HTR5A, MC5R, CHRNA5 | RECQL 3148/4885DRD2 59/4885DRD3 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.