Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068549 | 0.81 | MEN1 (0.45) | KMT2AKDM4EMEN1RXFP1MAPT | |
| SCHEMBL6068576 | 0.74 | GABRA1 (0.59) | ALDH1A1PKMGABRA1GABRG2GABRB3 | |
| SCHEMBL6068326 | 0.71 | GABRA1 (0.62) | KMT2AKDM4EALDH1A1MEN1RXFP1 | |
| SCHEMBL6068443 | 0.71 | POLB (0.41) | KMT2AALDH1A1MEN1RXFP1MAPT | |
| SCHEMBL6068711 | 0.70 | GABRA1 (0.46) | KMT2AKDM4EALDH1A1MEN1RXFP1 | |
| SCHEMBL6068720 | 0.70 | GABRG2 (0.49) | KMT2AMEN1RXFP1GABRA1GABRG2 | |
| SCHEMBL6068331 | 0.70 | RXFP1 (0.36) | KMT2AKDM4EALDH1A1MEN1RXFP1 | |
| SCHEMBL6068712 | 0.70 | GABRA1 (0.46) | KMT2AKDM4EALDH1A1MEN1RXFP1 | |
| SCHEMBL6068706 | 0.70 | POLB (0.36) | KMT2AKDM4EALDH1A1MEN1RXFP1 | |
| SCHEMBL6068520 | 0.68 | HPGD (0.51) | KMT2AKDM4EALDH1A1MEN1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | disclosed |