Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.61 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6069381 | 1.00 | PTPN1 (0.61) | PTPN1IKBKBCA1CA2BCHE | |
| SCHEMBL6069045 | 0.84 | PTPN1 (0.61) | PTPN1IKBKBCA1CA2BCHE | |
| SCHEMBL6068841 | 0.82 | PTPN1 (0.73) | PTPN1IKBKBLMNATHRBMEN1 | |
| SCHEMBL6069089 | 0.78 | PTPN1 (0.70) | PTPN1IKBKBLMNATHRBPPARA | |
| SCHEMBL6069281 | 0.77 | PTPN1 (0.67) | PTPN1MEN1KMT2A | |
| SCHEMBL6069138 | 0.76 | PTPN1 (0.61) | PTPN1IKBKBLMNATHRBCHKA | |
| SCHEMBL6069273 | 0.76 | PTPN1 (1.00) | PTPN1IKBKBLMNATHRBMEN1 | |
| SCHEMBL2117755 | 0.73 | LMNA (0.53) | CA1CA2ACHELMNACYP1A2 | |
| SCHEMBL2165990 | 0.73 | LMNA (0.53) | CA1CA2ACHELMNACYP1A2 | |
| SCHEMBL2117754 | 0.73 | LMNA (0.53) | CA1CA2ACHELMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141672-B2 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2006-11-28 | — | — | US | disclosed |
| US-20040147755-A1 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2004-07-29 | — | — | US | disclosed |
| US-6699896-B1 | METABOLIC DISORDERS, ANTIDIABETIC AGENTS; OBESITY | WYETH | 2004-03-02 | — | — | US | disclosed |
| EP-1077958-A1 | OXAZOLE-ARYL-CARBOXYLIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058511-A1 | OXAZOLE-ARYL-CARBOXYLIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147755-A1 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia | GPR119, INSR, GCKR | PTPN1 870/4885IKBKB 2010/4885CA1 1519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.