Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.61 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6069381 | 0.84 | PTPN1 (0.61) | PTPN1IKBKBLMNATHRBCA1 | |
| SCHEMBL6069378 | 0.84 | PTPN1 (0.61) | PTPN1IKBKBLMNATHRBCA1 | |
| SCHEMBL6068841 | 0.82 | PTPN1 (0.73) | PTPN1IKBKBLMNATHRBPPARD | |
| SCHEMBL7737825 | 0.82 | SMO (0.51) | PTPN1BRD4 | |
| SCHEMBL6069089 | 0.81 | PTPN1 (0.70) | PTPN1IKBKBLMNATHRBNOTUM | |
| SCHEMBL6069281 | 0.80 | PTPN1 (0.67) | PTPN1MAOB | |
| SCHEMBL10748706 | 0.79 | PTPN1 (0.48) | PTPN1IKBKBLMNATHRBNOTUM | |
| SCHEMBL9260216 | 0.77 | PPARG (0.53) | PTPN1PPARAPPARDPPARG | |
| SCHEMBL2268468 | 0.76 | KIF11 (0.56) | CA1CA2 | |
| SCHEMBL6069138 | 0.76 | PTPN1 (0.61) | PTPN1IKBKBLMNATHRBPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141672-B2 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2006-11-28 | — | — | US | disclosed |
| US-20040147755-A1 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2004-07-29 | — | — | US | disclosed |
| US-6699896-B1 | METABOLIC DISORDERS, ANTIDIABETIC AGENTS; OBESITY | WYETH | 2004-03-02 | — | — | US | disclosed |
| EP-1077958-A1 | OXAZOLE-ARYL-CARBOXYLIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058511-A1 | OXAZOLE-ARYL-CARBOXYLIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147755-A1 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia | GPR119, INSR, GCKR | PTPN1 870/4885IKBKB 2010/4885LMNA 3921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.