Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | TOP2A | P11388 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094353 | 0.78 | KDM4E (0.49) | MAPK1LMNAMAPTRAB9ATDP1 | |
| Bazinaprine SCHEMBL499295 | 0.77 | ACHE (1.00) | ACHECYP1A2CYP3A4CYP2D6CLK4 | |
| Bazinaprine SCHEMBL10830678 | 0.76 | ACHE (0.98) | ACHECYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL19051440 | 0.75 | RXFP1 (0.65) | MAPK1LMNAMAPTRAB9ATDP1 | |
| SCHEMBL7519805 | 0.75 | KMT2A (0.59) | ACHECYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL1256953 | 0.74 | ACHE (0.56) | ACHECYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL31060861 | 0.74 | TOP2A (0.65) | CYP1A2CYP3A4CYP2D6CLK4CYP2C19 | |
| SCHEMBL9208466 | 0.74 | LMNA (0.62) | ACHECYP1A2CYP3A4CYP2D6TOP2A | |
| SCHEMBL17254999 | 0.73 | ALDH1A1 (0.59) | ACHECYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL18057384 | 0.72 | ALDH1A1 (0.57) | ACHECYP1A2CYP3A4CYP2D6CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | ACHE 1541/4885CYP1A2 1959/4885CYP3A4 2706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.