Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | STK17B | O94768 | 1/20 | 0.45 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.45 |
| ▸ | DAPK2 | Q9UIK4 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071111 | 0.81 | CNR1 (0.46) | ROCK2ROCK1KDM4EKMT2AALDH1A1 | |
| SCHEMBL6449770 | 0.79 | ROCK2 (0.35) | ROCK2ROCK1STK17ASTK17BMAPT | |
| SCHEMBL6449766 | 0.79 | ROCK2 (0.35) | ROCK2ROCK1STK17ASTK17BMAPT | |
| SCHEMBL6071127 | 0.77 | NPC1 (0.51) | KDM4EALDH1A1MAPTSMN1; SMN2TP53 | |
| SCHEMBL6071485 | 0.77 | MAOB (0.56) | KMT2AALDH1A1MAPTMEN1SMN1; SMN2 | |
| SCHEMBL6071209 | 0.77 | VCP (0.46) | SMN1; SMN2NPC1RAB9AHPGDJAK2 | |
| SCHEMBL6070591 | 0.76 | CTNNB1 (0.52) | KDM4EKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL6070986 | 0.74 | RAB9A (0.46) | ROCK2STK17AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6071196 | 0.73 | KMT2A (0.57) | STK17AKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL5583293 | 0.73 | ACHE (0.46) | KDM4EKMT2AALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264493-A1 | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K1, MAP3K19, MAP3K20 | ROCK2 698/4885ROCK1 604/4885STK17A 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.