Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7243938 | 1.00 | ADRB3 (0.65) | ADRB3LMNAKDM4EADRB2ADRB1 | |
| SCHEMBL9445125 | 1.00 | ADRB3 (0.65) | ADRB3LMNAKDM4EADRB2ADRB1 | |
| SCHEMBL7244119 | 0.87 | ADRB3 (0.61) | ADRB3LMNAKDM4EADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL9134531 | 0.83 | HPGD (0.50) | ADRB3LMNAKDM4EADRB2ADRB1 | |
| SCHEMBL9447441 | 0.83 | LMNA (0.65) | ADRB3LMNAKDM4EADRB2ADRB1 | |
| SCHEMBL6075074 | 0.83 | LMNA (0.65) | ADRB3LMNAKDM4EADRB2ADRB1 | |
| SCHEMBL6499356 | 0.83 | LMNA (0.65) | ADRB3LMNAKDM4EADRB2ADRB1 | |
| SCHEMBL6074523 | 0.83 | LMNA (0.65) | ADRB3LMNAKDM4EADRB2ADRB1 | |
| SCHEMBL11420225 | 0.82 | ADRB3 (0.61) | ADRB3LMNAKDM4EADRB2ADRB1 | |
| SCHEMBL9688351 | 0.81 | ADRB2 (0.72) | ADRB3LMNAKDM4EADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7022716-B2 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH (US) | 2006-04-04 | — | — | US | disclosed |
| US-20030144326-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH | 2003-07-31 | — | — | US | disclosed |
| US-6525202-B2 | E.g., substituted (4-amino-5-hydroxyphenyl)-oxy-)piperidinyl thiazolidin-2,4-dione; antidiabetic agents; atherosclerosis, gastrointestinal, metabolic disorders, glaucoma, neurogenetic inflammation, ocular hypertension and frequent urination | WYETH | 2003-02-25 | — | — | US | disclosed |
| US-20020028835-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | WYETH | 2002-03-07 | — | — | US | disclosed |
| EP-0338793-B1 | Anti-hypertensive sulfonanilides | WELLCOME FOUND (GB) | 1993-10-27 | — | — | EP | disclosed |
| US-5194450-A | Hypotensive agents | BURROUGHS WELLCOME CO. (US) | 1993-03-16 | — | — | US | disclosed |
| US-5102914-A | Racemic mixtures | BURROUGHS WELLCOME CO. (US) | 1992-04-07 | — | — | US | disclosed |
| EP-0338793-A2 | Anti-hypertensive sulfonanilides | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-10-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144326-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | ADRB1, ADRB3, ADRB2 | ADRB3 2/4885LMNA 2593/4885KDM4E 4266/4885 |
| US-20020028835-A1 | Cyclic amine phenyl beta-3 adrenergic receptor agonists | ADRB1, ADRB3, ADRB2 | ADRB3 2/4885LMNA 2593/4885KDM4E 4266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.