SCHEMBL607476

SCHEMBL607476

O=C(CCc1ccccc1)NC(c1ccccc1O)c1cc(Cl)c2cccnc2c1O

nearest known ligand 0.74

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 5/20 0.74
RAB9A P51151 3/20 0.74
MEN1 O00255 2/20 0.74
ALDH1A1 P00352 2/20 0.74
KMT2A Q03164 2/20 0.74
ADAMTS5 Q9UNA0 15/20 0.67
ADAMTS4 O75173 1/20 0.64
KDM4E B2RXH2 2/20 0.59
TDP1 Q9NUW8 2/20 0.59
USP2 O75604 1/20 0.59
LMNA P02545 1/20 0.59
TP53 P04637 1/20 0.59
ALOX15 P16050 1/20 0.59
TSHR P16473 1/20 0.59
ALOX12 P18054 1/20 0.59
HTT P42858 1/20 0.59
NPC1 O15118 2/20 0.58
NPSR1 Q6W5P4 1/20 0.58
POLB P06746 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL610254 0.93 ADAMTS5 (0.76) HSP90AA1RAB9AMEN1ALDH1A1KMT2A
SCHEMBL610546 0.91 HSP90AA1 (0.72) HSP90AA1RAB9AMEN1ALDH1A1KMT2A
SCHEMBL1815008 0.90 HSP90AA1 (0.77) HSP90AA1RAB9AMEN1ALDH1A1KMT2A
SCHEMBL610665 0.88 ADAMTS5 (0.74) HSP90AA1RAB9AMEN1ALDH1A1KMT2A
SCHEMBL1812851 0.88 ADAMTS5 (0.74) HSP90AA1RAB9AMEN1ALDH1A1KMT2A
SCHEMBL608085 0.87 KDM4E (0.79) HSP90AA1RAB9AMEN1ALDH1A1KMT2A
SCHEMBL608917 0.86 ADAMTS5 (0.78) HSP90AA1RAB9AMEN1ALDH1A1KMT2A
SCHEMBL609432 0.86 HSP90AA1 (0.71) HSP90AA1RAB9AMEN1ALDH1A1KMT2A
SCHEMBL609898 0.85 HSP90AA1 (1.00) HSP90AA1RAB9AMEN1ALDH1A1KMT2A
SCHEMBL1813346 0.85 ADAMTS5 (0.72) HSP90AA1RAB9AMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210198244-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2021-07-01 US claimed
US-20170334890-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2017-11-23 US claimed
US-9695157-B2 Small molecule activators of mitochondrial function THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2017-07-04 US claimed
US-20150210674-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2015-07-30 US claimed
US-20120041023-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-02-16 US claimed
WO-2010068767-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2010-06-17 WO claimed
US-20210198244-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2021-07-01 US disclosed
US-10745390-B2 Small molecule activators of mitochondrial function THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2020-08-18 US disclosed
US-20170334890-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2017-11-23 US disclosed
US-9695157-B2 Small molecule activators of mitochondrial function THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2017-07-04 US disclosed
US-20150210674-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2015-07-30 US disclosed
US-9000009-B2 Small molecule activators of mitochondrial function THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2015-04-07 US disclosed
US-20120041023-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2012-02-16 US disclosed
WO-2010068767-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2010-06-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150210674-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION TFAM, TFB2M, GFM1 HSP90AA1 585/4885RAB9A 1259/4885MEN1 4113/4885
US-20170334890-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION TFAM, TFB2M, GFM1 HSP90AA1 585/4885RAB9A 1259/4885MEN1 4113/4885
US-20120041023-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION TFAM, TFB2M, GFM1 HSP90AA1 599/4885RAB9A 1391/4885MEN1 4050/4885
US-10745390-B2 Small molecule activators of mitochondrial function TFAM, TFB2M, GFM1 HSP90AA1 585/4885RAB9A 1259/4885MEN1 4113/4885
US-20210198244-A1 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION TFAM, TFB2M, GFM1 HSP90AA1 585/4885RAB9A 1259/4885MEN1 4113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.