Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478667 | 0.87 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL6074971 | 0.86 | CRHR1 (0.80) | CRHR1 | |
| SCHEMBL6075508 | 0.85 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL6075119 | 0.84 | CRHR1 (0.70) | CRHR1 | |
| SCHEMBL6075122 | 0.82 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL7474926 | 0.81 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL5411684 | 0.81 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL27501034 | 0.78 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL5530867 | 0.74 | CRHR1 (0.80) | CRHR1 | |
| SCHEMBL5411499 | 0.74 | CRHR1 (0.80) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6995161-B2 | Substituted arylpyrazines | NEUROGEN CORPORATION (US) | 2006-02-07 | — | — | US | claimed |
| CN-1231473-C | Substituted arylpyrazines | NEUROGEN CORP (US) | 2005-12-14 | — | — | CN | claimed |
| EP-1500653-A1 | Substituted arylpyrazines | Neurogen Corporation (US) | 2005-01-26 | — | — | EP | claimed |
| CN-1400970-A | Substituted arylpyrazines | NEUROGEN CORP (US) | 2003-03-05 | — | — | CN | claimed |
| US-20030018035-A1 | Substituted arylpyrazines | NEUROGEN CORPORATION | 2003-01-23 | — | — | US | claimed |
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018035-A1 | Substituted arylpyrazines | CRHR1, CRHR2, CRH | CRHR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.