Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077347 | 0.91 | LMNA (0.55) | LMNAKMT2AHPGDALDH1A1MEN1 | |
| SCHEMBL6078071 | 0.82 | ALDH1A1 (0.71) | LMNAKMT2AHPGDALDH1A1MEN1 | |
| SCHEMBL6078444 | 0.80 | LMNA (0.60) | LMNAKMT2AHPGDALDH1A1MEN1 | |
| SCHEMBL14142610 | 0.78 | LMNA (0.80) | LMNAKMT2AHPGDALDH1A1MEN1 | |
| SCHEMBL6076056 | 0.78 | ALDH1A1 (0.58) | LMNAKMT2AHPGDALDH1A1MEN1 | |
| SCHEMBL6077138 | 0.78 | LMNA (0.65) | LMNAKMT2AHPGDALDH1A1MEN1 | |
| SCHEMBL6077390 | 0.78 | ACKR3 (0.45) | LMNAKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL21525430 | 0.77 | EPHX1 (0.61) | ALDH1A1 | |
| SCHEMBL6075612 | 0.76 | ALDH1A1 (0.58) | LMNAKMT2AHPGDALDH1A1MEN1 | |
| SCHEMBL14559633 | 0.75 | ADAM17 (0.57) | LMNAALDH1A1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7098247-B2 | Arylene-carboxylic acid (2-amino-phenyl)-amide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-08-29 | — | — | US | disclosed |