Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 2/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.43 |
| ▸ | IDH2 | P48735 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079084 | 0.89 | PRMT1 (0.55) | PRMT1SIRT1PHGDH | |
| SCHEMBL6078726 | 0.85 | PRMT1 (0.72) | PRMT1SIRT1 | |
| SCHEMBL6079153 | 0.85 | PRMT1 (0.72) | PRMT1SIRT1 | |
| SCHEMBL6078800 | 0.84 | PRMT1 (0.74) | PRMT1SIRT1 | |
| SCHEMBL6078502 | 0.83 | PRMT1 (0.58) | PRMT1SIRT1 | |
| SCHEMBL6079150 | 0.82 | PRMT1 (0.72) | PRMT1SIRT1 | |
| SCHEMBL6079522 | 0.81 | MEN1 (0.62) | PRMT1IDH2IDH1 | |
| SCHEMBL6077709 | 0.81 | TCF4 (0.57) | PRMT1SIRT1IDH1 | |
| SCHEMBL6078378 | 0.78 | PRMT1 (0.61) | PRMT1SIRT1ALDH1A1 | |
| SCHEMBL6079091 | 0.78 | PRMT1 (0.64) | PRMT1SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1181271-B1 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK INC (US) | 2005-01-19 | — | — | EP | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |