Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | XBP1 | P17861 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | IDH1 | O75874 | 7/20 | 0.58 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.56 |
| ▸ | IDH2 | P48735 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6078726 | 0.84 | PRMT1 (0.72) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL6079153 | 0.84 | PRMT1 (0.72) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL6078800 | 0.83 | PRMT1 (0.74) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL6078502 | 0.82 | PRMT1 (0.58) | MEN1KMT2APOLBPRMT1 | |
| SCHEMBL6079150 | 0.81 | PRMT1 (0.72) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL6078879 | 0.81 | PRMT1 (0.57) | IDH1PRMT1IDH2 | |
| SCHEMBL12113068 | 0.80 | MEN1 (0.78) | MEN1KMT2ALMNATP53MAPT | |
| SCHEMBL6079084 | 0.80 | PRMT1 (0.55) | LMNAPRMT1 | |
| SCHEMBL6077709 | 0.80 | TCF4 (0.57) | MEN1KMT2ALMNAMAPTPOLB | |
| SCHEMBL12112970 | 0.78 | MEN1 (0.74) | MEN1KMT2ALMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1181271-B1 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK INC (US) | 2005-01-19 | — | — | EP | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |