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SCHEMBL6079084

SCHEMBL6079084

O=C(O)Cc1cccc(NS(=O)(=O)c2cc(O)c3ccc(NC(=O)Nc4ccc5c(O)cc(S(=O)(=O)Nc6cccc(CC(=O)O)c6)cc5c4)cc3c2)c1

nearest known ligand 0.72

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ PRMT1 Q99873 2/20 0.55
▸ SIRT1 Q96EB6 1/20 0.53
▸ HPSE Q9Y251 1/20 0.52
▸ SELP P16109 2/20 0.46
▸ SELE P16581 2/20 0.46
▸ FABP4 P15090 1/20 0.46
▸ PHGDH O43175 1/20 0.46
▸ SELL P14151 1/20 0.44
▸ PFKFB3 Q16875 1/20 0.43
▸ LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6078879 0.89 PRMT1 (0.57) PRMT1SIRT1PHGDH
SCHEMBL6078502 0.84 PRMT1 (0.58) PRMT1SIRT1HPSEPFKFB3
SCHEMBL6079153 0.83 PRMT1 (0.72) PRMT1SIRT1
SCHEMBL6078726 0.83 PRMT1 (0.72) PRMT1SIRT1
SCHEMBL6078800 0.82 PRMT1 (0.74) PRMT1SIRT1
SCHEMBL6079150 0.81 PRMT1 (0.72) PRMT1SIRT1
SCHEMBL6079522 0.80 MEN1 (0.62) PRMT1LMNA
SCHEMBL6078378 0.79 PRMT1 (0.61) PRMT1SIRT1
SCHEMBL6077709 0.79 TCF4 (0.57) PRMT1SIRT1PFKFB3LMNA
SCHEMBL6079091 0.78 PRMT1 (0.64) PRMT1SIRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7071231-B2 Naphthalene ureas as glucose uptake enhancers TELIK, INC. (US) 2006-07-04 — — US disclosed
EP-1181271-B1 NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS TELIK INC (US) 2005-01-19 — — EP disclosed
US-6458998-B1 NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS TELIK, INC. 2002-10-01 — — US disclosed