Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | IKBKB | O14920 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | STAT5A | P42229 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079206 | 0.90 | MEN1 (0.51) | LMNAALDH1A1TSHRMAPTIKBKB | |
| SCHEMBL6079143 | 0.90 | ALDH1A1 (0.64) | LMNAALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL6078679 | 0.86 | LMNA (0.56) | LMNAALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL6079922 | 0.86 | MAPT (0.60) | LMNAALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL6078415 | 0.85 | ALDH1A1 (0.59) | LMNAALDH1A1GAAL3MBTL1TSHR | |
| SCHEMBL6079074 | 0.85 | LMNA (0.54) | LMNAALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL6078607 | 0.83 | MEN1 (0.53) | ALDH1A1TSHRIKBKBJAK2ROCK2 | |
| SCHEMBL6078277 | 0.82 | LMNA (0.67) | LMNAALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL6079588 | 0.80 | LMNA (0.49) | LMNAALDH1A1GAAL3MBTL1MAPT | |
| SCHEMBL6078676 | 0.80 | LMNA (0.64) | LMNAALDH1A1GAAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |