Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | PLAU | P00749 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PPIA | P62937 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079143 | 0.95 | ALDH1A1 (0.64) | ALDH1A1GAALMNAL3MBTL1PLAU | |
| SCHEMBL6079922 | 0.92 | MAPT (0.60) | ALDH1A1GAALMNAL3MBTL1PLAU | |
| SCHEMBL6078679 | 0.88 | LMNA (0.56) | ALDH1A1GAALMNAL3MBTL1MAPT | |
| SCHEMBL6078277 | 0.87 | LMNA (0.67) | ALDH1A1GAALMNAL3MBTL1PLAU | |
| SCHEMBL6079074 | 0.86 | LMNA (0.54) | ALDH1A1GAALMNAL3MBTL1MAPT | |
| SCHEMBL6079183 | 0.85 | LMNA (0.53) | ALDH1A1GAALMNAL3MBTL1KDM4E | |
| SCHEMBL6078220 | 0.85 | TP53 (0.58) | ALDH1A1 | |
| SCHEMBL6078676 | 0.85 | LMNA (0.64) | ALDH1A1GAALMNAL3MBTL1PLAU | |
| SCHEMBL6429403 | 0.83 | LMNA (0.62) | ALDH1A1GAALMNAL3MBTL1MAPT | |
| SCHEMBL6079643 | 0.81 | ALDH1A1 (0.65) | ALDH1A1GAALMNAL3MBTL1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |