Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ATIC | P31939 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079658 | 0.90 | GAA (0.62) | AKR1C3ALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL6079752 | 0.88 | AKR1C3 (0.70) | AKR1C3MEN1KMT2A | |
| SCHEMBL6078632 | 0.86 | GAA (0.60) | AKR1C3ALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL28666883 | 0.86 | AKR1C3 (0.71) | WDR5AKR1C3TDP1ALDH1A1GAA | |
| SCHEMBL6078913 | 0.85 | KDM4E (0.67) | ALDH1A1GAALMNASMN1; SMN2HSD17B10 | |
| SCHEMBL6078674 | 0.84 | AKR1C3 (0.69) | AKR1C3MEN1KMT2A | |
| SCHEMBL6079475 | 0.83 | PRMT1 (0.62) | WDR5MEN1KMT2ACYP2C9ATIC | |
| SCHEMBL6079117 | 0.80 | AKR1C3 (0.79) | AKR1C3MEN1KMT2AHSD17B10 | |
| SCHEMBL6077413 | 0.80 | NPC1 (0.62) | AKR1C3ALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL6429561 | 0.80 | MEN1 (0.55) | AKR1C3ALDH1A1GAALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1181271-B1 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK INC (US) | 2005-01-19 | — | — | EP | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |