Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | ATIC | P31939 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6078632 | 0.96 | GAA (0.60) | GAACYP2C9ATICCYP2C19HSD17B10 | |
| SCHEMBL6079407 | 0.90 | WDR5 (0.59) | GAACYP2C9ATICCYP2C19HSD17B10 | |
| SCHEMBL6429561 | 0.88 | MEN1 (0.55) | GAAALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL6427777 | 0.88 | PLAU (0.66) | GAACYP2C9ATICCYP2C19HSD17B10 | |
| SCHEMBL7782154 | 0.87 | ALDH1A1 (0.77) | GAACYP2C9ATICCYP2C19HSD17B10 | |
| SCHEMBL6079752 | 0.87 | AKR1C3 (0.70) | MEN1KMT2AAKR1C3POLBMAPT | |
| SCHEMBL6079320 | 0.85 | PLAU (0.73) | GAAALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL6079195 | 0.85 | TP53 (0.60) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6077413 | 0.84 | NPC1 (0.62) | GAAALDH1A1LMNASMN1; SMN2CA2 | |
| SCHEMBL6078674 | 0.83 | AKR1C3 (0.69) | MEN1KMT2AAKR1C3POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |