Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4523780 | 0.89 | PIN1 (0.42) | ALDH1A1CCR6PAX8ALOX5L3MBTL1 | |
| SCHEMBL11307171 | 0.83 | ALDH1A1 (0.47) | ALDH1A1CCR6PAX8ALOX5L3MBTL1 | |
| SCHEMBL16488805 | 0.81 | CCR6 (0.47) | ALDH1A1CCR6PAX8ALOX5L3MBTL1 | |
| SCHEMBL3423094 | 0.80 | ALOX5 (0.51) | ALDH1A1CCR6PAX8ALOX5L3MBTL1 | |
| SCHEMBL15194247 | 0.79 | CCR6 (0.48) | ALDH1A1CCR6PAX8ALOX5L3MBTL1 | |
| SCHEMBL15275367 | 0.79 | CCR6 (0.45) | ALDH1A1CCR6PAX8ALOX5L3MBTL1 | |
| SCHEMBL3212998 | 0.79 | CCR6 (0.45) | ALDH1A1CCR6PAX8ALOX5L3MBTL1 | |
| SCHEMBL15183633 | 0.78 | ALOX5 (0.49) | ALDH1A1CCR6PAX8ALOX5L3MBTL1 | |
| SCHEMBL3228835 | 0.78 | ALDH1A1 (0.42) | ALDH1A1CCR6PAX8ALOX5L3MBTL1 | |
| Hydrochloric Acid SCHEMBL15266733 | 0.78 | CCR6 (0.44) | ALDH1A1CCR6PAX8ALOX5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122662-B2 | Tricyclic compound having spiro union | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2006-10-17 | — | — | US | disclosed |
| US-20050148769-A1 | Tricyclic compound having spiro union | MOCHIDA PHARMACEUTICAL CO., LTD. | 2005-07-07 | — | — | US | disclosed |
| US-6858599-B2 | Inhibitor for activated blood coagulation factor X | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2005-02-22 | — | — | US | disclosed |
| EP-1191028-B1 | TRICYCLIC COMPOUNDS HAVING SPIRO UNION | MOCHIDA PHARM CO LTD (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-20030045520-A1 | Tricyclic compound having spiro union | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-06 | — | — | US | disclosed |
| EP-1191028-A1 | TRICYCLIC COMPOUNDS HAVING SPIRO UNION | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045520-A1 | Tricyclic compound having spiro union | F2, TFPI, F11 | ALDH1A1 1073/4885CCR6 3068/4885PAX8 4041/4885 |
| US-20050148769-A1 | Tricyclic compound having spiro union | TFPI, F2, F12 | ALDH1A1 1791/4885CCR6 3031/4885PAX8 4007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.