SCHEMBL6079941

SCHEMBL6079941

NCc1nccc(C(F)(F)F)c1Cl

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 4/20 0.41
LOX P28300 2/20 0.40
LOXL3 P58215 1/20 0.36
PREP P48147 4/20 0.34
IDO1 P14902 2/20 0.34
P2RX7 Q99572 2/20 0.33
NOS3 P29474 1/20 0.32
NOS2 P35228 1/20 0.32
PIK3CD O00329 1/20 0.32
NOTUM Q6P988 2/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
HDAC5 Q9UQL6 1/20 0.31
KDM5A P29375 1/20 0.31
KDM4C Q9H3R0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19583845 0.83 P2RX7 (0.34) LOXL2PREPIDO1P2RX7NOTUM
SCHEMBL3080095 0.81 P2RX7 (0.36) PREPIDO1P2RX7NOTUM
SCHEMBL21120953 0.81 P2RX7 (0.35) PREPP2RX7
Hydrochloric Acid SCHEMBL19583921 0.81 P2RX7 (0.33) LOXL2LOXPREPIDO1P2RX7
SCHEMBL20088854 0.75 NOS2 (0.39) LOXL2P2RX7NOS3NOS2PIK3CD
SCHEMBL31097846 0.75 NOS2 (0.39) LOXL2P2RX7NOS3NOS2PIK3CD
SCHEMBL6348523 0.74 LOXL2 (0.42) LOXL2LOXLOXL3
SCHEMBL364870 0.74 P2RX7 (0.36) P2RX7NOS3NOS2PIK3CDNOTUM
SCHEMBL2301406 0.73 CXCR4 (0.45) LOXL2LOXIDO1
SCHEMBL27333817 0.73 LOXL2 (0.37) LOXL2LOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4554931-A1 PROCESS FOR PREPARING SUBSTITUTED BENZAMIDES ADAMA MAKHTESHIM LTD. (IL) 2025-05-21 EP disclosed
WO-2024013736-A1 PROCESS FOR PREPARING SUBSTITUTED BENZAMIDES ADAMA MAKHTESHIM LTD. (IL) 2024-01-18 WO disclosed
US-20060004206-A1 Novel process for the preparation of 2-aminomethylpyridine derivative BAYER CROPSCIENCE S.A. (FR) 2006-01-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060004206-A1 Novel process for the preparation of 2-aminomethylpyridine derivative AZI2, IL4I1, ABL2 LOXL2 3033/4885LOX 1682/4885LOXL3 4207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.