Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 4/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | F13A1 | P00488 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15987129 | 0.83 | TGM2 (0.55) | TGM2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL22118553 | 0.82 | TGM2 (0.56) | TGM2STAT3F13A1TGM1TGM3 | |
| SCHEMBL13659673 | 0.81 | NPSR1 (0.69) | MEN1KMT2ARAB9AALDH1A1NPSR1 | |
| SCHEMBL27453091 | 0.81 | ALDH1A1 (0.56) | PARP14RAB9AALDH1A1NPSR1NPC1 | |
| SCHEMBL8686785 | 0.81 | KMT2A (0.64) | MEN1KMT2ARAB9AALDH1A1NPSR1 | |
| SCHEMBL1925142 | 0.81 | KMT2A (0.71) | TGM2MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL13662571 | 0.79 | L3MBTL1 (0.61) | MEN1KMT2ARAB9AALDH1A1NPC1 | |
| SCHEMBL6194954 | 0.78 | TGM2 (0.50) | TGM2MEN1KMT2A | |
| SCHEMBL6081313 | 0.78 | POLB (0.51) | ALDH1A1STAT3ABCB1ABCG2 | |
| SCHEMBL2025451 | 0.78 | SLC7A5 (0.51) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060079503-A1 | Thiazolidinones and the use therof as polo-like kinase inhibitors | SCHERING AKTIENGESELLSCHAFT | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079503-A1 | Thiazolidinones and the use therof as polo-like kinase inhibitors | PLK4, PLK2, PLK3 | TGM2 808/4885HIF1A 2756/4885HDAC3 2899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.