Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.69 |
| ▸ | MAOB | P27338 | 6/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081884 | 0.94 | TMEM97 (0.60) | TMEM97SIGMAR1MAOBACHESLC6A2 | |
| SCHEMBL1728503 | 0.86 | LTA4H (0.54) | TMEM97SIGMAR1HRH3LTA4HKCNH2 | |
| SCHEMBL1728694 | 0.86 | KDM4E (0.56) | SIGMAR1HRH3LTA4HKCNH2MCHR1 | |
| SCHEMBL6081563 | 0.85 | LTA4H (0.55) | HRH3LTA4HKCNH2MCHR1 | |
| SCHEMBL5888854 | 0.83 | TMEM97 (1.00) | TMEM97SIGMAR1MAOBSLC6A2SLC6A4 | |
| SCHEMBL6081461 | 0.82 | HRH3 (0.52) | TMEM97SIGMAR1HRH3LTA4HKCNH2 | |
| SCHEMBL1727661 | 0.82 | LTA4H (0.60) | HRH3LTA4HKCNH2MCHR1 | |
| SCHEMBL6081329 | 0.82 | MCHR1 (0.49) | TMEM97SIGMAR1HRH3LTA4HKCNH2 | |
| SCHEMBL1728674 | 0.81 | ALDH1A1 (0.60) | HRH3LTA4HKCNH2MCHR1KDM4E | |
| SCHEMBL1728438 | 0.81 | LTA4H (0.56) | HRH3LTA4HKCNH2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |