Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 8/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081391 | 1.00 | LTA4H (0.54) | LTA4HMEN1KMT2APOLBPTGER4 | |
| SCHEMBL6081581 | 0.86 | LTA4H (0.50) | LTA4HPTGER4PTGER2ALDH1A1KDM4E | |
| SCHEMBL1729474 | 0.83 | HRH3 (0.57) | HRH3KCNH2 | |
| SCHEMBL1727398 | 0.80 | NPC1 (0.49) | LTA4HNPC1RAB9AHRH3KCNH2 | |
| SCHEMBL6081377 | 0.80 | LTA4H (0.44) | LTA4HPTGER4PTGER2HRH3KCNH2 | |
| SCHEMBL6081517 | 0.80 | LTA4H (0.45) | LTA4HHRH3KCNH2MCHR1 | |
| SCHEMBL6081914 | 0.79 | MCHR1 (0.48) | LTA4HHRH3KCNH2MCHR1 | |
| SCHEMBL6081905 | 0.79 | MCHR1 (0.48) | LTA4HHRH3KCNH2MCHR1 | |
| SCHEMBL1727509 | 0.79 | LTA4H (0.42) | LTA4HPTGER4PTGER2ALDH1A1KDM4E | |
| SCHEMBL6081329 | 0.78 | MCHR1 (0.49) | LTA4HHRH3KCNH2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |