Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081641 | 0.81 | CDK4 (0.43) | CDK4CCND1AURKAPARP1CHEK1 | |
| SCHEMBL6081136 | 0.70 | DDB1 (0.33) | GABRA5GABRG2GABRB3POLB | |
| SCHEMBL6080498 | 0.67 | CDK4 (0.56) | CDK4CCND1AURKAPARP1CHEK1 | |
| SCHEMBL6080838 | 0.67 | ROCK2 (0.48) | CDK4CCND1PARP1CDK5CDK5R1 | |
| SCHEMBL22566992 | 0.64 | CDK4 (0.83) | CDK4CCND1AURKAPARP1CHEK1 | |
| SCHEMBL4039665 | 0.64 | DAO (0.47) | AURKAPARP1GABRA5GABRA1 | |
| SCHEMBL16504230 | 0.63 | CDK4 (0.60) | CDK4CCND1PARP1CHEK1GABRA5 | |
| SCHEMBL6081548 | 0.61 | CDK4 (0.39) | CDK4CCND1PARP1CHEK1 | |
| SCHEMBL12396544 | 0.60 | AURKA (0.65) | AURKAPARP1CHEK1FEN1KDM4E | |
| SCHEMBL30322758 | 0.60 | AURKA (0.65) | AURKAPARP1CHEK1FEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004428-A1 | Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-01-05 | — | — | US | disclosed |