Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.56 |
| ▸ | CCND1 | P24385 | 8/20 | 0.56 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6080997 | 0.81 | CDK4 (0.61) | CDK4CCND1GSK3BCHEK1PARP1 | |
| SCHEMBL22566992 | 0.79 | CDK4 (0.83) | CDK4CCND1GSK3BCHEK1PARP1 | |
| SCHEMBL6081058 | 0.74 | CDK4 (0.50) | CDK4CCND1GSK3BCLK1CHEK1 | |
| SCHEMBL6081478 | 0.73 | ROCK2 (0.64) | CDK4GSK3BCLK1CHEK1PRKCA | |
| SCHEMBL6080935 | 0.73 | CDK4 (0.60) | CDK4CCND1GSK3BCLK1CHEK1 | |
| SCHEMBL9262153 | 0.72 | CDK4 (1.00) | CDK4CCND1GSK3BCHEK1PARP1 | |
| SCHEMBL14346099 | 0.69 | PARP1 (0.66) | CDK4CCND1CHEK1PARP1 | |
| SCHEMBL6081708 | 0.69 | CHEK1 (0.61) | CDK4CCND1CHEK1CCNE2PRKACA | |
| SCHEMBL9259173 | 0.68 | CDK4 (0.74) | CDK4CCND1GSK3BCHEK1PRKCA | |
| SCHEMBL6081576 | 0.67 | CDK4 (0.41) | CDK4CCND1GSK3BCLK1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004428-A1 | Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-01-05 | — | — | US | disclosed |