Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.48 |
| ▸ | CDK4 | P11802 | 8/20 | 0.47 |
| ▸ | CCND1 | P24385 | 8/20 | 0.47 |
| ▸ | PRKCA | P17252 | 8/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.43 |
| ▸ | PRKCG | P05129 | 4/20 | 0.43 |
| ▸ | PRKCB | P05771 | 4/20 | 0.43 |
| ▸ | PRKCH | P24723 | 4/20 | 0.43 |
| ▸ | PRKCI | P41743 | 4/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081666 | 0.85 | CDK4 (0.46) | CDK4CCND1PRKCAPARP1CCNE2 | |
| SCHEMBL6086984 | 0.85 | CHEK1 (0.48) | ROCK2PRKCAPRKCQPRKCDCDK5 | |
| SCHEMBL6081548 | 0.85 | CDK4 (0.39) | ROCK2CDK4CCND1PRKCAPARP1 | |
| SCHEMBL6080997 | 0.81 | CDK4 (0.61) | CDK4CCND1PRKCAPARP1PRKD3 | |
| SCHEMBL6080842 | 0.80 | CHEK1 (0.52) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL5438544 | 0.79 | PRKCA (0.71) | ROCK2CDK4CCND1PRKCAPARP1 | |
| SCHEMBL14708732 | 0.77 | ROCK2 (0.58) | ROCK2CDK4CCND1PRKCAPARP1 | |
| SCHEMBL8122606 | 0.74 | CDK4 (0.77) | ROCK2CDK4CCND1PRKCAPRKD3 | |
| SCHEMBL12270180 | 0.73 | CHEK1 (0.46) | ROCK2CDK4CCND1PRKCAPARP1 | |
| SCHEMBL6080907 | 0.70 | PRKCA (0.57) | ROCK2CDK4CCND1PRKCAPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004428-A1 | Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-01-05 | — | — | US | disclosed |