Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
| ▸ | PDE8A | O60658 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.39 |
| ▸ | PDE8B | O95263 | 1/20 | 0.39 |
| ▸ | PDE6A | P16499 | 1/20 | 0.39 |
| ▸ | PDE6G | P18545 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE6B | P35913 | 1/20 | 0.39 |
| ▸ | PDE6C | P51160 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081576 | 0.81 | CDK4 (0.41) | CDK4CCND1AURKAPARP1MAPT | |
| SCHEMBL6081831 | 0.71 | DDB1 (0.35) | POLBFEN1GABRG2GABRB3GABRA5 | |
| SCHEMBL22566992 | 0.66 | CDK4 (0.83) | CDK4CCND1AURKAPARP1MAPT | |
| SCHEMBL6080838 | 0.66 | ROCK2 (0.48) | CDK4CCND1PARP1MAPT | |
| SCHEMBL6080498 | 0.66 | CDK4 (0.56) | CDK4CCND1AURKAPARP1MAPT | |
| SCHEMBL16504230 | 0.64 | CDK4 (0.60) | CDK4CCND1PARP1GABRA1GABRG2 | |
| SCHEMBL10809784 | 0.64 | FEN1 (0.54) | AURKAPARP1PDE2APDE6DPDE8A | |
| SCHEMBL12396544 | 0.62 | AURKA (0.65) | AURKAPARP1MAPTKDM4EHTT | |
| SCHEMBL30322758 | 0.62 | AURKA (0.65) | AURKAPARP1MAPTKDM4EHTT | |
| SCHEMBL5879136 | 0.62 | AURKA (0.49) | CDK4CCND1AURKAPARP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004428-A1 | Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-01-05 | — | — | US | disclosed |