Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8715671 | 0.94 | ALDH1A1 (0.48) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8713051 | 0.94 | ALDH1A1 (0.48) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8712572 | 0.94 | ALDH1A1 (0.48) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7623485 | 0.80 | CYP1A2 (0.46) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4278139 | 0.80 | CYP1A2 (0.46) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL161069 | 0.76 | CYP2C19 (0.50) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 | |
| Triphenylmethanol SCHEMBL456603 | 0.76 | CYP19A1 (0.50) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31357395 | 0.76 | CYP1A2 (0.48) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7173455 | 0.76 | CYP1A2 (0.48) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 | |
| Triphenylmethanol SCHEMBL1332873 | 0.76 | CYP19A1 (0.50) | ALDH1A1TSHRCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817366-B9 | MIXED ALKYL BENZYL ESTER OF SUCCINIC ACID AS SOFTENER | LANXESS DEUTSCHLAND GMBH (DE) | 2017-09-06 | — | — | EP | disclosed |
| EP-2817366-B1 | MIXED ALKYL BENZYL ESTER OF SUCCINIC ACID AS SOFTENER | LANXESS DEUTSCHLAND GMBH (DE) | 2017-04-12 | — | — | EP | disclosed |
| EP-2217576-B1 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | UNIV MICHIGAN (US) | 2016-05-11 | — | — | EP | disclosed |
| US-9080032-B2 | Mixed alkyl benzyl esters of succinic acid used as plasticizers | LANXESS DEUTSCHLAND GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| US-20150114263-A1 | MIXED ALKYL BENZYL ESTERS OF SUCCINIC ACID USED AS PLASTICIZERS | LANXESS DEUTSCHLAND GMBH (DE) | 2015-04-30 | — | — | US | disclosed |
| EP-2817366-A1 | MIXED ALKLY BENZYL ESTERS OF SUCCINIC ACID USED AS PLASTICIZERS | Lanxess Deutschland GmbH (DE) | 2014-12-31 | — | — | EP | disclosed |
| US-8759340-B2 | Benzodiazepinone compounds useful in the treatment of skin conditions | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-06-24 | — | — | US | disclosed |
| US-8673897-B2 | Benzodiazepinone compounds and methods of treatment using same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-03-18 | — | — | US | disclosed |
| US-8604023-B2 | 1,4-benzodiazepinone compounds and their use in treating cancer | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-12-10 | — | — | US | disclosed |
| US-20130274197-A1 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-10-17 | — | — | US | disclosed |
| US-20120040971-A1 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-02-16 | — | — | US | disclosed |
| WO-2011035124-A1 | BENZODIAZEPINONE COMPOUNDS AND METHODS OF TREATMENT USING SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-03-24 | — | — | WO | disclosed |
| CN-101918375-A | Benzodiazepinone compounds useful in the treatment of skin conditions | UNIV MICHIGAN | 2010-12-15 | — | — | CN | disclosed |
| WO-2010121164-A2 | 1,4-BENZODIAZEPINONE COMPOUNDS AND THEIR USE IN TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-10-21 | — | — | WO | disclosed |
| EP-2217576-A2 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | The Regents of the University of Michigan (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061916-A2 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-14 | — | — | WO | disclosed |
| US-20090118244-A1 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-07 | — | — | US | disclosed |
| US-20080004387-A1 | Alkyl benzyl esters of polycarboxylic acids | LANXESS DEUTSCHLAND GMBH (DE) | 2008-01-03 | — | — | US | disclosed |
| EP-1873198-A1 | Mixtures of alkyl esters and benzyl esters of polycarboxylic acids | Lanxess Deutschland GmbH (DE) | 2008-01-02 | — | — | EP | disclosed |
| EP-0010154-A1 | Soil insecticides containing substituted benzylcyclopropane carboxylates (I) as active compounds, preparation of these insecticides, control of soil insects by the esters (I) and substituted benzylcyclopropane carboxylates | BAYER AG (DE) | 1980-04-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040971-A1 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | RORC, RORA, RORB | ALDH1A1 373/4885TSHR 2217/4885CYP1A2 79/4885 |
| US-20090118244-A1 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | RORC, RORA, RORB | ALDH1A1 373/4885TSHR 2217/4885CYP1A2 79/4885 |
| US-20130274197-A1 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | RORC, RORA, RORB | ALDH1A1 373/4885TSHR 2217/4885CYP1A2 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.