Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.48 |
| ▸ | WEE1 | P30291 | 5/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 3/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081666 | 0.87 | CDK4 (0.46) | CHEK1WEE1GSK3BCDK5CDK5R1 | |
| SCHEMBL6081548 | 0.87 | CDK4 (0.39) | CHEK1WEE1ROCK2PRKCA | |
| SCHEMBL6080838 | 0.85 | ROCK2 (0.48) | ROCK2GSK3BCDK5CDK5R1GSK3A | |
| SCHEMBL6081478 | 0.83 | ROCK2 (0.64) | CHEK1WEE1ROCK2GSK3BCDK5 | |
| SCHEMBL6080842 | 0.81 | CHEK1 (0.52) | CHEK1 | |
| SCHEMBL8498825 | 0.70 | CHEK1 (0.79) | CHEK1ROCK2CDK5CDK5R1PRKCA | |
| SCHEMBL6081058 | 0.70 | CDK4 (0.50) | CHEK1WEE1ROCK2GSK3BCDK5 | |
| SCHEMBL6080935 | 0.69 | CDK4 (0.60) | CHEK1WEE1ROCK2GSK3BCDK5 | |
| SCHEMBL10075906 | 0.68 | CHEK1 (0.52) | CHEK1WEE1ROCK2GSK3BCDK5 | |
| SCHEMBL6080997 | 0.66 | CDK4 (0.61) | CHEK1GSK3BCDK5CDK5R1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004428-A1 | Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-01-05 | — | — | US | disclosed |