Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.60 |
| ▸ | CCND1 | P24385 | 8/20 | 0.60 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.60 |
| ▸ | CDK2 | P24941 | 5/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.60 |
| ▸ | CDK1 | P06493 | 3/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.60 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.51 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.51 |
| ▸ | CAMK2A | Q9UQM7 | 3/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081058 | 0.87 | CDK4 (0.50) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6081478 | 0.86 | ROCK2 (0.64) | CDK4CDK5CDK5R1ROCK2CHEK1 | |
| SCHEMBL6080997 | 0.84 | CDK4 (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6081666 | 0.83 | CDK4 (0.46) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL8127688 | 0.79 | CDK4 (0.86) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6081708 | 0.78 | CHEK1 (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6080498 | 0.73 | CDK4 (0.56) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6081548 | 0.71 | CDK4 (0.39) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL6086984 | 0.69 | CHEK1 (0.48) | CDK5CDK5R1ROCK2CHEK1WEE1 | |
| SCHEMBL6030439 | 0.68 | CDK4 (0.86) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004428-A1 | Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-01-05 | — | — | US | disclosed |