Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.61 |
| ▸ | CCND1 | P24385 | 10/20 | 0.61 |
| ▸ | PRKCG | P05129 | 6/20 | 0.61 |
| ▸ | PRKCB | P05771 | 6/20 | 0.61 |
| ▸ | PRKCA | P17252 | 6/20 | 0.61 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.61 |
| ▸ | CDK2 | P24941 | 6/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.61 |
| ▸ | PRKCH | P24723 | 5/20 | 0.61 |
| ▸ | PRKCI | P41743 | 5/20 | 0.61 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.61 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.61 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.61 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.61 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.61 |
| ▸ | CAMK2B | Q13554 | 5/20 | 0.61 |
| ▸ | CAMK2G | Q13555 | 5/20 | 0.61 |
| ▸ | CAMK2D | Q13557 | 5/20 | 0.61 |
| ▸ | CAMK2A | Q9UQM7 | 5/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081058 | 0.85 | CDK4 (0.50) | CDK4CCND1PRKCGPRKCBPRKCA | |
| SCHEMBL6080935 | 0.84 | CDK4 (0.60) | CDK4CCND1PRKCGPRKCBPRKCA | |
| SCHEMBL6081478 | 0.84 | ROCK2 (0.64) | CDK4PRKCGPRKCBPRKCAPRKD3 | |
| SCHEMBL6080838 | 0.81 | ROCK2 (0.48) | CDK4CCND1PRKCGPRKCBPRKCA | |
| SCHEMBL6080498 | 0.81 | CDK4 (0.56) | CDK4CCND1PRKCGPRKCBPRKCA | |
| SCHEMBL6081708 | 0.78 | CHEK1 (0.61) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Staurosporine Aglycon SCHEMBL29406635 | 0.77 | CDK4 (1.00) | CDK4CCND1PRKCGPRKCBPRKCA | |
| Staurosporine Aglycon SCHEMBL8124103 | 0.77 | CDK4 (1.00) | CDK4CCND1PRKCGPRKCBPRKCA | |
| Staurosporine Aglycon SCHEMBL30530825 | 0.77 | CDK4 (1.00) | CDK4CCND1PRKCGPRKCBPRKCA | |
| SCHEMBL12270180 | 0.76 | CHEK1 (0.46) | CDK4CCND1PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004428-A1 | Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-01-05 | — | — | US | claimed |
| US-20060004428-A1 | Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2006-01-05 | — | — | US | disclosed |