Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 6/20 | 0.55 |
| ▸ | MAOA | P21397 | 4/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088959 | 0.90 | MAOB (0.48) | HIF1AMAOBSMPD1RAB9ANPC1 | |
| SCHEMBL6088473 | 0.89 | HIF1A (0.57) | HIF1AMAOBNR4A2SMPD1LMNA | |
| SCHEMBL6088371 | 0.88 | RXRA (0.46) | HIF1AMAOBMAOASMPD1RAB9A | |
| SCHEMBL6088680 | 0.88 | NR4A2 (0.62) | HIF1AMAOBMAOANR4A2SMPD1 | |
| SCHEMBL6088771 | 0.87 | NR4A2 (0.58) | HIF1ANR4A2RAB9ANPC1MAPT | |
| SCHEMBL6088578 | 0.86 | NR4A2 (0.57) | HIF1AMAOBNR4A2SMPD1RAB9A | |
| SCHEMBL6090155 | 0.85 | NR4A2 (0.57) | HIF1AMAOBMAOANR4A2RAB9A | |
| SCHEMBL6088329 | 0.85 | MAOB (0.52) | HIF1AMAOBNR4A2RAB9ANPC1 | |
| SCHEMBL6088416 | 0.85 | ADAM17 (0.47) | HIF1ANPC1ADAM17MAPT | |
| SCHEMBL6088781 | 0.83 | MAOB (0.44) | HIF1AMAOBNR4A2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |