Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088473 | 0.91 | HIF1A (0.57) | MAOBHIF1ALMNAMRGPRX4SMPD1 | |
| SCHEMBL6087974 | 0.90 | HIF1A (0.58) | MAOBHIF1ARAB9AMAPTLMNA | |
| SCHEMBL6092100 | 0.89 | RXRA (0.51) | MAOBHIF1AMRGPRX4RXRARXRB | |
| SCHEMBL6088578 | 0.88 | NR4A2 (0.57) | MAOBHIF1ARAB9AMAPTLMNA | |
| SCHEMBL6088371 | 0.88 | RXRA (0.46) | MAOBHIF1ARAB9AMAPTLMNA | |
| SCHEMBL6088329 | 0.87 | MAOB (0.52) | MAOBHIF1ARAB9AMAPTLMNA | |
| SCHEMBL6088416 | 0.87 | ADAM17 (0.47) | HIF1AMAPTMRGPRX4NPC1 | |
| SCHEMBL6088853 | 0.86 | CYSLTR1 (0.43) | HIF1ARAB9AMAPTLMNAMRGPRX4 | |
| SCHEMBL6088781 | 0.85 | MAOB (0.44) | MAOBHIF1ARAB9AMAPTLMNA | |
| SCHEMBL6089138 | 0.84 | MAOB (0.59) | MAOBRAB9AMRGPRX4NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |