Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 4/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.36 |
| ▸ | PFKFB1 | P16118 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6635822 | 0.93 | SLC6A4 (0.56) | SLC6A4HTR1ARORCCNR1CNR2 | |
| SCHEMBL3886520 | 0.85 | SLC6A4 (0.51) | SLC6A4HTR1ARORCCNR1CNR2 | |
| SCHEMBL6637096 | 0.84 | HTR1A (0.53) | SLC6A4HTR1ARORCCNR1CNR2 | |
| SCHEMBL7972314 | 0.82 | SLC6A4 (0.44) | SLC6A4HTR1ARORCCNR1CNR2 | |
| SCHEMBL6636440 | 0.78 | SMO (0.54) | SLC6A4HTR1ACNR2PTGDR2 | |
| SCHEMBL6636075 | 0.77 | SLC6A4 (0.53) | SLC6A4HTR1ARORCCNR1CNR2 | |
| SCHEMBL6087259 | 0.76 | SLC6A4 (0.62) | SLC6A4HTR1ARORCCNR1CNR2 | |
| SCHEMBL6088184 | 0.76 | SLC6A4 (0.62) | SLC6A4HTR1ARORCCNR1CNR2 | |
| SCHEMBL6087846 | 0.76 | SLC6A4 (0.62) | SLC6A4HTR1ARORCCNR1CNR2 | |
| SCHEMBL6087263 | 0.76 | SLC6A4 (0.62) | SLC6A4HTR1ARORCCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049314-B2 | Sexual disorders; antidepressants; attention deficit hyperactivity, obsessive-compulsive, and/or post-traumatic stress disorder; drug abuse and addiction | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-23 | — | — | US | disclosed |
| US-20040077705-A1 | Cyclopentyl indole derivatives | BRISTOL-MYERS SQUIBB COMPANY | 2004-04-22 | — | — | US | disclosed |
| WO-2004026236-A2 | CYCLOPENTYL INDOLE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077705-A1 | Cyclopentyl indole derivatives | HTR5A, TPH1, TPH2 | SLC6A4 11/4885HTR1A 4/4885RORC 931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.