Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 12/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090965 | 0.88 | MRGPRX4 (0.60) | MAOBMRGPRX4MAOANPC1ALDH1A1 | |
| SCHEMBL6088473 | 0.88 | HIF1A (0.57) | MAOBMRGPRX4ALDH1A1SMN1; SMN2 | |
| SCHEMBL6089804 | 0.85 | FFAR1 (0.50) | MAOBMRGPRX4FFAR1FFAR4 | |
| SCHEMBL6088959 | 0.84 | MAOB (0.48) | MAOBMRGPRX4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6088329 | 0.84 | MAOB (0.52) | MAOBMRGPRX4NPC1RAB9AFFAR1 | |
| SCHEMBL6088416 | 0.84 | ADAM17 (0.47) | MRGPRX4NPC1 | |
| SCHEMBL6087974 | 0.82 | HIF1A (0.58) | MAOBMAOANPC1RAB9A | |
| SCHEMBL6088781 | 0.82 | MAOB (0.44) | MAOBMRGPRX4NPC1RAB9A | |
| SCHEMBL5724594 | 0.81 | HIF1A (0.53) | MAOBMRGPRX4NPC1ALDH1A1RAB9A | |
| SCHEMBL6088371 | 0.81 | RXRA (0.46) | MAOBMRGPRX4MAOANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |