Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.48 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TLR4 | O00206 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088500 | 0.92 | PTGDR2 (0.46) | PTGDR2GPR132LMNANPC1RAB9A | |
| SCHEMBL6088697 | 0.86 | PTGDR2 (0.46) | PTGDR2LMNANPC1RAB9ANR4A2 | |
| SCHEMBL6092205 | 0.85 | PTGDR2 (0.53) | PTGDR2LMNANPC1RAB9ANR4A2 | |
| SCHEMBL6090648 | 0.84 | MEN1 (0.48) | PTGDR2LMNANPC1RAB9ANR4A2 | |
| SCHEMBL6089761 | 0.84 | GPR132 (0.49) | GPR132NPC1RAB9ANR4A2PARP10 | |
| SCHEMBL6091148 | 0.83 | PTGDR2 (0.47) | PTGDR2GPR132LMNANR4A2FFAR1 | |
| SCHEMBL6089372 | 0.83 | CYSLTR1 (0.62) | — | |
| SCHEMBL6089925 | 0.81 | ABCB1 (0.42) | GPR132NPC1RAB9ANR4A2KDM4E | |
| SCHEMBL5725340 | 0.81 | PPARA (0.54) | PTGDR2NPC1RAB9AFFAR1PPARG | |
| SCHEMBL6090684 | 0.81 | NR4A2 (0.46) | PTGDR2NPC1RAB9ANR4A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |