Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.39 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092205 | 0.89 | PTGDR2 (0.53) | PTGDR2LMNAPPARGPPARDPLA2G4B | |
| SCHEMBL6088500 | 0.87 | PTGDR2 (0.46) | PTGDR2LMNAPPARGPPARDPLA2G4B | |
| SCHEMBL6089340 | 0.86 | PTGDR2 (0.48) | PTGDR2LMNAPPARGNPC1NR4A2 | |
| SCHEMBL6089251 | 0.85 | SLC26A4 (0.49) | LMNAPPARGSLC26A4NPC1NR4A2 | |
| SCHEMBL6089139 | 0.82 | SMN1; SMN2 (0.36) | LMNAPPARGNPC1NR4A2RAB9A | |
| SCHEMBL6090183 | 0.82 | PTGER1 (0.50) | PTGDR2LMNAPPARGPPARDPLA2G4B | |
| SCHEMBL6091148 | 0.81 | PTGDR2 (0.47) | PTGDR2LMNAPPARGPPARDNR4A2 | |
| SCHEMBL6088801 | 0.78 | GPR132 (0.51) | PPARGPPARDPPARA | |
| SCHEMBL6089768 | 0.78 | MRGPRX4 (0.49) | PTGDR2PPARGPPARDPLA2G4BFFAR1 | |
| SCHEMBL6088820 | 0.78 | FFAR1 (0.55) | PTGDR2PPARDNR4A2FFAR1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |