Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.49 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | TLR4 | O00206 | 1/20 | 0.45 |
| ▸ | TLR2 | O60603 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090266 | 0.91 | SLC26A4 (0.46) | GPR132SLC26A4NPC1NR4A2RAB9A | |
| SCHEMBL6091097 | 0.89 | GPR132 (0.47) | GPR132SLC26A4NPC1NR4A2RAB9A | |
| SCHEMBL6088689 | 0.88 | NPC1 (0.46) | GPR132NPC1RAB9APARP10TLR4 | |
| SCHEMBL6088674 | 0.86 | SLC26A4 (0.63) | SLC26A4NPC1NR4A2RAB9AMAOB | |
| SCHEMBL6089251 | 0.85 | SLC26A4 (0.49) | SLC26A4NPC1NR4A2RAB9AMAOB | |
| SCHEMBL6089164 | 0.84 | PTGER4 (0.47) | SLC26A4NPC1NR4A2RAB9APTGER4 | |
| SCHEMBL6088808 | 0.84 | SLC26A4 (0.46) | SLC26A4NPC1NR4A2RAB9APTGER4 | |
| SCHEMBL6089340 | 0.84 | PTGDR2 (0.48) | GPR132NPC1NR4A2RAB9APARP10 | |
| SCHEMBL6091032 | 0.83 | NR4A2 (0.48) | SLC26A4NPC1NR4A2RAB9APPARG | |
| SCHEMBL4450809 | 0.83 | NR4A2 (0.58) | SLC26A4NR4A2MAOBKDM4EPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| CN-1183113-C | Tri-aryl acid derivatives as PPAR receptor ligands | ���ĵ�˹ҩ��¹�����˾ | 2005-01-05 | — | — | CN | disclosed |
| CN-1356983-A | Tri-aryl acid derivatives as PPAR receptor ligands | AVENTIS PHARM PROD INC (DE) | 2002-07-03 | — | — | CN | disclosed |