Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84268 | 0.81 | CYP3A4 (0.41) | TSHRCYP1A2CYP3A4MAPK1ADRB2 | |
| SCHEMBL5801533 | 0.78 | CYP1A2 (0.36) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL27784531 | 0.77 | CYP3A4 (0.43) | TSHRCYP1A2CYP3A4MAPK1ADRB2 | |
| SCHEMBL27999832 | 0.75 | CD44 (0.43) | TSHRCYP3A4LMNAALDH1A1HPGD | |
| SCHEMBL11469208 | 0.75 | LMNA (0.41) | TSHRCYP1A2CYP3A4ADRB1ADRB3 | |
| SCHEMBL5118561 | 0.74 | ALDH1A1 (0.44) | TSHRCYP3A4ADRB2ADRB1LMNA | |
| SCHEMBL26599490 | 0.70 | ADRA2A (0.41) | TSHRADRB1ADRB3LMNAL3MBTL1 | |
| SCHEMBL21899485 | 0.69 | CYP3A4 (0.50) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1981235 | 0.68 | TSHR (0.47) | TSHRCYP1A2MAPK1CYP2C9CYP2C19 | |
| SCHEMBL2522991 | 0.68 | SMN1; SMN2 (0.42) | TSHRLMNAL3MBTL1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6998489-B2 | Methods of making indazoles | ALCON, INC. (CH) | 2006-02-14 | — | — | US | disclosed |
| EP-1392659-A4 | METHODS OF MAKING INDAZOLES | ALCON INC (CH) | 2004-10-20 | — | — | EP | disclosed |
| US-20040142998-A1 | Methods of making indazoles | ALCON, INC. (CH) | 2004-07-22 | — | — | US | disclosed |
| EP-1392659-A1 | METHODS OF MAKING INDAZOLES | Alcon, Inc. (CH) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002098862-A1 | METHODS OF MAKING INDAZOLES | ALCON, INC. (CH) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142998-A1 | Methods of making indazoles | NAT1, CYP3A5, ALDH3A1 | TSHR 4510/4885CYP1A2 11/4885CYP3A4 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.