Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981089 | 0.81 | MAPT (0.56) | MAPTSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL3401020 | 0.81 | MAPK1 (0.64) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL6979367 | 0.81 | MAPT (0.57) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL11313450 | 0.80 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL7158014 | 0.79 | MAPT (0.64) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL2762136 | 0.78 | MAPT (0.67) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL22077613 | 0.78 | ALDH1A1 (0.54) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL3634489 | 0.77 | HSD17B1 (0.63) | MAPTSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL3086399 | 0.76 | MAPT (0.61) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2792432 | 0.76 | ABL1 (0.64) | MAPTSMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |