Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CASP2 | P42575 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SCD | O00767 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981089 | 0.84 | MAPT (0.56) | MAPTMAOBHSD17B1HSD17B2MAOA | |
| SCHEMBL6975865 | 0.84 | TP53 (0.51) | MAPTMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6982879 | 0.82 | PDPK1 (0.49) | MAPTMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6983733 | 0.81 | DYRK1A (0.48) | MAPTMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6090647 | 0.81 | MAPT (0.55) | MAPTMAOBHSD17B1HSD17B2MAOA | |
| SCHEMBL7158014 | 0.79 | MAPT (0.64) | MAPTMAOBHSD17B1HSD17B2MAOA | |
| SCHEMBL2762136 | 0.78 | MAPT (0.67) | MAPTMAOBHSD17B1HSD17B2MAOA | |
| SCHEMBL6979211 | 0.78 | RAB9A (0.58) | MAPTMAOBHSD17B1HSD17B2NPC1 | |
| SCHEMBL3634489 | 0.77 | HSD17B1 (0.63) | MAPTMAOBHSD17B1HSD17B2MAOA | |
| SCHEMBL3086399 | 0.76 | MAPT (0.61) | MAPTMAOBHSD17B1HSD17B2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006114-B1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | GRELAN PHARMACEUTICAL CO (JP) | 2003-01-22 | — | — | EP | disclosed |
| US-6136831-A | ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL AGENTS, ENZYME INHIBITORS | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-1006114-A1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | Grelan Pharmaceutical Co., Ltd. (JP) | 2000-06-07 | — | — | EP | disclosed |