Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CFB | P00751 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092642 | 0.98 | ALOX15 (0.42) | ALOX15KMT2AMEN1HSD17B10ALDH1A1 | |
| SCHEMBL6089632 | 0.84 | HSD17B10 (0.44) | KMT2AMEN1HSD17B10ALDH1A1KDM4E | |
| SCHEMBL7125283 | 0.84 | PDGFRB (0.34) | ALOX15KMT2AMEN1HSD17B10ALDH1A1 | |
| SCHEMBL5401530 | 0.83 | MCL1 (0.40) | KMT2AMEN1HSD17B10ALDH1A1KDM4E | |
| SCHEMBL7117376 | 0.83 | ALDH1A1 (0.34) | KMT2AMEN1HSD17B10ALDH1A1KDM4E | |
| SCHEMBL6089855 | 0.83 | HRH3 (0.42) | ALOX15KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL7125898 | 0.82 | ALDH1A1 (0.43) | HSD17B10ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL6092029 | 0.81 | PDGFRB (0.46) | ALOX15KMT2AL3MBTL1MAPT | |
| SCHEMBL7117883 | 0.81 | HRH3 (0.42) | KMT2AMEN1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL7128643 | 0.81 | TRPV6 (0.35) | KMT2AMEN1HSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |