SCHEMBL609166

SCHEMBL609166

CN(C)c1cccc(C(=S)c2ccccc2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
POLB P06746 2/20 0.50
LMNA P02545 2/20 0.50
ALDH1A1 P00352 5/20 0.48
TSHR P16473 1/20 0.48
RAB9A P51151 4/20 0.46
NPC1 O15118 3/20 0.46
MAPT P10636 3/20 0.46
MAPK1 P28482 1/20 0.46
KDM4E B2RXH2 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
GFER P55789 2/20 0.45
HSD17B10 Q99714 1/20 0.45
HPGD P15428 3/20 0.44
MEN1 O00255 2/20 0.44
HSP90AA1 P07900 1/20 0.44
GAA P10253 1/20 0.44
TMEM97 Q5BJF2 1/20 0.42
SIGMAR1 Q99720 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10945624 0.84 POLB (0.53) KMT2AL3MBTL1POLBLMNAALDH1A1
SCHEMBL611876 0.82 RAB9A (0.64) KMT2AL3MBTL1ALDH1A1TSHRRAB9A
SCHEMBL609848 0.80 ALDH1A1 (0.53) KMT2AL3MBTL1LMNAALDH1A1TSHR
SCHEMBL12808789 0.78 ALDH1A1 (0.57) KMT2AL3MBTL1POLBLMNAALDH1A1
SCHEMBL609636 0.77 KMT2A (0.69) KMT2AL3MBTL1POLBLMNAALDH1A1
SCHEMBL610059 0.77 HPGD (0.69) KMT2AL3MBTL1POLBLMNAALDH1A1
SCHEMBL27888995 0.77 RAB9A (0.69) KMT2AL3MBTL1POLBLMNAALDH1A1
SCHEMBL222176 0.76 KMT2A (0.58) KMT2AL3MBTL1POLBLMNAALDH1A1
SCHEMBL29625195 0.76 KMT2A (0.58) KMT2AL3MBTL1POLBLMNAALDH1A1
SCHEMBL12154048 0.76 LMNA (0.60) KMT2AL3MBTL1POLBLMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2857446-B1 TREAD RUBBER COMPOSITION AND PNEUMATIC TIRE SUMITOMO RUBBER IND (JP) 2018-03-07 EP disclosed
US-9790359-B2 Tread rubber composition and pneumatic tire SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2017-10-17 US disclosed
CN-104334629-B Rubber composition for tire tread and pneumatic tire 住友橡胶工业株式会社 2016-08-24 CN disclosed
US-20150099823-A1 TREAD RUBBER COMPOSITION AND PNEUMATIC TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2015-04-09 US disclosed
EP-2857446-A1 TREAD RUBBER COMPOSITION AND PNEUMATIC TIRE Sumitomo Rubber Industries, Ltd. (JP) 2015-04-08 EP disclosed
CN-104334629-A Tread rubber composition and pneumatic tire SUMITOMO RUBBER IND 2015-02-04 CN disclosed
US-8334339-B2 Conjugated diene-based polymer, conjugated diene-based polymer composition, and process for producing conjugated diene-based polymer SUMITOMO CHEMICAL CO., LTD. (JP) 2012-12-18 US disclosed
US-20120041134-A1 CONJUGATED DIENE-BASED POLYMER, CONJUGATED DIENE-BASED POLYMER COMPOSITION, AND PROCESS FOR PRODUCING CONJUGATED DIENE-BASED POLYMER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-16 US disclosed