Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731708 | 0.90 | ALDH1A1 (0.50) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL5731755 | 0.90 | KDM4E (0.48) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL6090758 | 0.89 | KDM4E (0.46) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL5731692 | 0.81 | ALDH1A1 (0.42) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL6091508 | 0.79 | MEN1 (0.44) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL21776525 | 0.77 | SMN1; SMN2 (0.41) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL16830867 | 0.73 | GABRA2 (0.45) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL6092387 | 0.73 | ALDH1A1 (0.46) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL22730883 | 0.72 | ALDH1A1 (0.60) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL6493537 | 0.72 | HMGCR (0.45) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006059210-A2 | FUSED BICYCLIC PYRROLS AS HMG-COA REDUCTASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2006-06-08 | — | — | WO | disclosed |