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SCHEMBL6092916

SCHEMBL6092916

CN(C)C(CCN(OC(=O)C(=O)ON(CCC(c1ccc(Cl)cc1)N(C)C)C(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)Nc1ccc(C(F)(F)F)cc1)c1ccc(Cl)cc1

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ UTS2R Q9UKP6 9/20 0.55
▸ RHOC P08134 1/20 0.43
▸ RHOA P61586 1/20 0.43
▸ SLC6A9 P48067 1/20 0.42
▸ MTOR P42345 1/20 0.41
▸ CNR1 P21554 1/20 0.40
▸ CNR2 P34972 1/20 0.40
▸ TSHR P16473 1/20 0.40
▸ PKM P14618 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ CCR1 P32246 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6093163 0.86 UTS2R (0.53) UTS2RPKMRAB9A
SCHEMBL6093296 0.85 UTS2R (0.54) UTS2RTSHR
SCHEMBL6094112 0.84 UTS2R (0.56) UTS2R
SCHEMBL5452743 0.84 UTS2R (0.63) UTS2RRHOCRHOASLC6A9MTOR
SCHEMBL6092652 0.81 UTS2R (0.56) UTS2RRAB9A
SCHEMBL6094333 0.79 UTS2R (0.61) UTS2RRHOCRHOASLC6A9CNR1
SCHEMBL6091360 0.78 UTS2R (0.53) UTS2R
SCHEMBL5452806 0.75 UTS2R (0.62) UTS2RCNR1TSHRRAB9A
SCHEMBL6091146 0.74 UTS2R (0.53) UTS2RRAB9A
SCHEMBL5463499 0.71 UTS2R (1.00) UTS2RSLC6A9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006135694-A2 UII-MODULATING COMPOUNDS AND THEIR USE ACADIA PHARMACEUTICALS INC. (US) 2006-12-21 — — WO disclosed