SCHEMBL6093296

SCHEMBL6093296

CN(C)C(CCN(OC(=O)C(=O)ON(CCC(c1ccc(Cl)cc1)N(C)C)C(=O)Nc1ccc(-c2ccccc2)cc1)C(=O)Nc1ccc(-c2ccccc2)cc1)c1ccc(Cl)cc1

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 14/20 0.54
NPY5R Q15761 2/20 0.42
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
TSHR P16473 1/20 0.40
MCHR1 Q99705 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6094112 0.91 UTS2R (0.56) UTS2RNPY5RALDH1A1L3MBTL1
SCHEMBL6093163 0.87 UTS2R (0.53) UTS2RALDH1A1L3MBTL1
SCHEMBL6092652 0.86 UTS2R (0.56) UTS2R
SCHEMBL6092916 0.85 UTS2R (0.55) UTS2RTSHR
SCHEMBL5458491 0.84 UTS2R (0.62) UTS2RMCHR1
SCHEMBL6091360 0.82 UTS2R (0.53) UTS2RL3MBTL1
SCHEMBL6091146 0.81 UTS2R (0.53) UTS2RKDM4EALDH1A1
SCHEMBL5463949 0.75 UTS2R (0.64) UTS2RNPY5RALDH1A1L3MBTL1
SCHEMBL6091406 0.71 UTS2R (0.62) UTS2RNPY5RALDH1A1L3MBTL1
SCHEMBL5463931 0.70 UTS2R (0.61) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006135694-A2 UII-MODULATING COMPOUNDS AND THEIR USE ACADIA PHARMACEUTICALS INC. (US) 2006-12-21 WO disclosed