Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11252528 | 0.89 | GAA (0.70) | GAAALDH1A1HTTTHRBMAPT | |
| SCHEMBL5028293 | 0.81 | GAA (0.61) | GAAALDH1A1HTTTHRBMAPT | |
| SCHEMBL11531629 | 0.79 | MAPT (0.55) | GAAALDH1A1AGERMAPTMEN1 | |
| SCHEMBL6161907 | 0.79 | THRB (0.66) | GAAALDH1A1HTTTHRBMAPT | |
| SCHEMBL10498902 | 0.79 | GAA (0.59) | GAAALDH1A1HTTTHRBAGER | |
| SCHEMBL2705170 | 0.79 | GAA (0.59) | GAAALDH1A1HTTTHRBMAPT | |
| SCHEMBL11142878 | 0.79 | GAA (0.59) | GAAALDH1A1HTTTHRBMAPT | |
| SCHEMBL13192623 | 0.78 | CA2 (0.46) | GAAALDH1A1AGERMAPTMEN1 | |
| SCHEMBL6554127 | 0.78 | GAA (0.58) | GAAALDH1A1HTTTHRBMAPT | |
| SCHEMBL141474 | 0.78 | GAA (0.58) | GAAALDH1A1HTTTHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106432246-B | Heteroaromatic compounds and their use in medicine | 广东东阳光药业有限公司 | 2020-07-07 | — | — | CN | disclosed |
| CN-105777756-B | Heteroaryl compound and its application in drug | 广东东阳光药业有限公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-106432246-A | Heteroaromatic compound and application thereof to drug | 广东东阳光药业有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-105777756-A | Heteroaryl compound and application thereof in medicines | 广东东阳光药业有限公司 | 2016-07-20 | — | — | CN | disclosed |
| US-20060128718-A1 | Tetrahydropyridazine derivatives having a pesticidal effect | BAYER CROPSCIENCE AG (DE) | 2006-06-15 | — | — | US | disclosed |
| EP-1537101-A1 | TETRAHYDROPYRIDAZINE DERIVATIVES HAVING A PESTICIDAL EFFECT | Bayer CropScience Aktiengesellschaft (DE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004024722-A1 | TETRAHYDROPYRIDAZINE DERIVATIVES HAVING A PESTICIDAL EFFECT | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128718-A1 | Tetrahydropyridazine derivatives having a pesticidal effect | DDT, ACHE, RDX | GAA 2443/4885ALDH1A1 1579/4885HTT 1151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.